Role of neopterin in cardiovascular medicine.

Rev Esp Cardiol. 2009;62(11):1332-44 1341 a better understanding of the kinetics of said markers could lead to improvements in their use in cardiovascular diseases. Considering the diversity of the diurnal variations in the intrinsic properties of the cardiovascular system, these should be kept in mind during the design of in vivo experimental studies. Such temporal decisions will undoubtedly reduce the discrepancies between the studies carried out in different laboratories, as well as between animal and human subjects. The majority of these clinical studies are carried out during daytime hours, when the subject is awake. As such, the information available reinforces our opinion when suitably validating the biomarkers and the need to demonstrate their reliability, stability, and lack of variability and standardise the methodology of their measurement.